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5-LO (phospho Ser523) rabbit pAb

簡要描述：SourceRabbitApplicationsWB,ELISAReactivityHuman,RatDilutionWB:1:500-1:2000

  • 產品型號：
  • 廠商性質：生產廠家
  • 更新時間：2024-05-16
  • 訪  問  量：71

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詳細介紹

  • Source

    Rabbit

  • Applications

    WB,ELISA

  • Reactivity

    Human,Rat

  • Dilution

    WB: 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

  • Storage

    -20°C/1 year

  • Specificity

    Phospho-5-LO (S523) Polyclonal Antibody detects endogenous levels of 5-LO protein only when phosphorylated at S523.

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    Synthesized phospho-peptide around the phosphorylation site of human 5-LO (phospho Ser523)

  • Uniprot No

    P09917

  • Alternative names

    ALOX5; LOG5; Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    arachidonate 5-lipoxygenase(ALOX5) Homo sapiens This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

  • Other

    ALOX5, Arachidonate 5-lipoxygenase

  • Mol.Wt (Da)

    77983

  • Concentration

    1 mg/ml

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