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CD274 rabbit pAb

簡要描述：SourceRabbitApplicationsIHC

  • 產(chǎn)品型號：
  • 廠商性質(zhì)：生產(chǎn)廠家
  • 更新時間：2024-05-16
  • 訪  問  量：70

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詳細(xì)介紹

  • Source

    Rabbit

  • Applications

    IHC,ELISA

  • Reactivity

    Human

  • Dilution

    IHC 1:50-200, ELISA 1:10000-20000

  • Storage

    -20°C/1 year

  • Specificity

    The antibody detects endogenous CD274

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    Synthetic peptide from human protein at AA range: 181-230

  • Uniprot No

    Q9NZQ7

  • Alternative names

    Programmed cell death 1 ligａnd 1 (PD-L1) (PDCD1 ligａnd 1) (Programmed death ligａnd 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    CD274 molecule(CD274) Homo sapiens This gene encodes an immune inhibitory receptor ligａnd that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligａnd with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

  • Other

    CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1, Programmed cell death 1 ligａnd 1 (PD-L1) (PDCD1 ligａnd 1) (Programmed death ligａnd 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)

  • Concentration

    1 mg/ml

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